In silico prediction models for thyroid peroxidase inhibitors and their application to synthetic flavors
출판일 : 2022.03. Abstract Systematic toxicity tests are often waived for the synthetic flavors as they are added in a very small amount in foods. However, their safety for some endpoints such as endocrine disruption should be concerned as they are likely to be active in low levels. In this case, structure–activity-relationship (SAR) models […]
Genotoxicity test of eight natural color additives in the Korean market
출판일 : 2022.06.08. Abstract Background: Various natural color additives are preferred by many consumers over synthetic color additives because they are perceived to be safer. However, most do not have sufficient toxicity data for safety assurance. Color ingredients in particular have some structures suspected of being toxic. Eight natural color additives, gardenia red, […]
Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet
출판일 : 2022.02.01. Abstract Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of hepatocellular carcinoma (HCC). Although the intracellular cholesterol accumulation has been demonstrated to regulate the gene expression responsible for steatohepatitis, the role played by cholesterol in the development of NAFLD-associated HCC has not been fully elucidated. In this […]
Soy isoflavone ameliorated the alterations in circulating adipokines and microRNAs of mice fed a high-fat diet
출판일 : 2022.10.13. Abstract Soy protein, containing isoflavones and bioactive peptides, is shown to have anti-obesity effects, but the main contributor and underlying mechanisms remain unclear. Recent studies have demonstrated that circulating microRNAs (miRNAs) act as important mediators in obesity and metabolic processes. In this study, we investigated whether soy protein components have […]
Regulation of gene expression in the development of colitis-associated colon cancer in mice fed a high-fat diet
출판일 : 2022.01.10 Abstract Studies have shown that the higher prevalence of colorectal cancers among patients with inflammatory bowel disease. Thus, proinflammatory stimulus due to a high-fat diet may impose a higher risk on the development of colorectal cancer. In the present study, we applied a transcriptomic approach to characterize the molecular mechanism(s) by […]
Effects of maternal branched-chain amino acid and alanine supplementation on growth and biomarkers of protein metabolism in dams fed a low-protein diet and their offspring
출판일 : 2022.03.30. Abstract A considerable number of studies have reported that maternal protein restriction may disturb fetal growth and organ development due to a lower availability of amino acids. Leucine, one of branched-chain amino acid (BCAA) promotes protein synthesis through mechanistic target of rapamycin signaling. Here, we investigated the effects of BCAA […]
Dietary vitamin B6 restriction aggravates neurodegeneration in mice fed a high-fat diet
출판일 : 2022.11.15 Abstract Aims: It is well known that a low-status of B vitamins is associated with cognitive impairment. However, the impact of vitamin B6 (VB6) restriction on neurodegenerative diseases and its underlying mechanisms are rarely understood. This study investigated whether VB6 restriction aggravates neurodegeneration in mice fed either a low-fat (LF) control […]
Luteolin Induces Apoptosis and Autophagy in HCT116 Colon Cancer Cells via p53-dependent pathway
출판일 : 2022. Abstract Although a dietary phytochemical luteolin has been shown to regulate various anticancer mechanisms, a role of luteolin in autophagy regulation is mostly unidentified. Here, we investigated whether luteolin exhibits its anticancer effects by induction of apoptosis and autophagy in a p53-dependent manner in colon cancer cells. Cell viability was determined […]
2023년 제5회 BK21 대학원혁신사업단 콜로키움 행사 안내
안녕하세요, BK21 지속가능 식품영양 교육연구팀입니다. 2023년 제5회 BK21 대학원혁신사업단 콜로키움 행사 안내드립니다. 이번 행사에는 대면 참여 뿐 아니라 비대면으로도 참여가 가능하오니 관심있으신 참여대학원생의 많은 참여 바랍니다. ******************************************************************************************** – 행사명 : 제 5회 BK21대학원혁신사업단 콜로키움 – 일 정 : 2023. 1. 17.(화) 14:00~16:00 – 참여방법 1) 행사장 대면 참여 – […]
2023년 1월 BK21 지속가능 식품영양 교육연구팀 세미나 시리즈 안내
안녕하세요 BK 지속가능 식품영양 교육연구팀입니다. 2023년 1월 전문가 초청 세미나를 안내드리오니, 많은 참석 바랍니다. ***************************************************************************** “서울대학교 BK21 지속가능 식품영양 교육연구팀 초청 세미나” -시간: 1월 18일 수요일 오전 10시 30분 ~ 11시 30분 -장소: 서울대학교 생활과학대학 222동 B102호 최병오홀 -강의 주제: – 푸드업사이클 산업의 배경 및 현황. – 푸드업사이클 산업에서의 창업 -연좌: 민명준 (주)리하베스트 […]
